Long noncoding RNAs (
lncRNA)
play pivotal
roles in every level of
gene and
genome regulation. MCM3AP-AS1 is a
lncRNA that has an oncogenic
role in several kinds of
cancers. Aberrant expression of MCM3AP-AS1 has been reported to be involved in the progression of diverse
malignancies, including colorectal, cervical,
prostate,
lymphoma,
lung,
ovary,
liver,
bone, and
breast cancers. It is generally believed that MCM3AP-AS1 expression is associated with
cancer cell growth, proliferation,
angiogenesis, and
metastasis. MCM3AP-AS1 by targeting various signaling pathways and
microRNAs (
miRNAs) presents an important
role in
cancer pathogenesis. MCM3AP-AS1 as a
competitive endogenous RNA has the
ability to
sponge miRNA, inhibit their expressions, and bind to different target mRNAs related to
cancer development. Therefore, MCM3AP-AS1 by targeting several signaling pathways, including the FOX
family, Wnt,
EGF, and
VEGF can be a potent target for
cancer prediction and
diagnosis. In this
review, we
will summarize the
role of MCM3AP-AS1 in various
human cancers (AU)