Swimming exercise versus L-carnosine supplementation for Alzheimers dementia in rats: implication of circulating and hippocampal FNDC5/irisin
Hegazy, Maha A; Abdelmonsif, Doaa A; Zeitoun, Teshreen M; El-Sayed, Norhan S; Samy, Doaa M.
J. physiol. biochem
; 78(1): 109-124, feb. 2022. graf
Artículo
en Inglés
| IBECS (España) | ID: ibc-215877
Recent studies have suggested that irisin may act as a potential neurokine. Exercise and L-carnosine supplementation showed neuroprotective effects in Alzheimers disease (AD)like conditions. However, the regulation of irisin in the hippocampus of streptozotocin (STZ)induced memory impairment and its relation to insulin signalling remain to be investigated. This study was designed to compare the effect of swimming exercise and L-carnosine intake on serum, CSF and hippocampal irisin in rats received intracerebroventricular (ICV) injection of STZ. Rats were recruited in swimming paradigm, received oral carnosine (100 mg/kg/day) or vehicle treated. After 5 weeks, rats were sacrificed after neurobehavioural testing. CSF and serum irisin were determined. Hippocampal tissues were used to assess expression of FNDC5/irisin, BDNF and proteins related to insulin signalling, in addition to β-amyloid peptide and phosphorylated tau protein levels. We observed decreased hippocampal, but not CSF or serum, irisin in ICV-STZ-injected rats. Exercise and carnosine intake almost normalized hippocampal FNDC5/irisin expression which was associated with reduced soluble β-amyloid peptide and phosphorylated tau protein, improved BDNF and insulin signalling proteins, with corresponding mitigated cognitive impairments. However, hippocampal FNDC5/irisin was not correlated with serum or CSF irisin levels. Histologically, both interventions ameliorated the hippocampal damage in STZ-injected rats. The current study reveals that carnosine is equivalent to exercise in reversing cognitive decline and Alzheimers biomarkers. In both interventions, enhancement of hippocampal FNDC5/irisin and insulin signalling may be involved in mediating these neuroprotective effects. (AU)
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ES1.1
Ubicación: ES15.1 - BNCS
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