Purpose This
paper aims to observe the expressions of
VEGF and
MMP-2 in
patients with
nasopharyngeal carcinoma treated by nimotuzumab combined with
cisplatin.
Methods Altogether, 104
patients with
nasopharyngeal carcinoma treated in our
hospital from April 2014 to August 2016 were selected as
research subjects. Among them, 50
patients treated with
cisplatin were divided into a
control group and 54
patients treated with nimotuzumab combined with
cisplatin were divided into an
observation group. The two groups of
patients were compared in terms of
efficacy after treatment and
incidence of adverse reactions. Changes of
serum VEGF and
MMP-2 concentrations before and
after treatment were detected using
enzyme-linked immunosorbent assay (
ELISA), and the 3-year overall
survival (OS) of
patients was observed. Results Compared with the
control group,
patients in the
observation group had significantly higher total remission rate (RR) (P < 0.05) and significantly lower
incidence of adverse reactions (P < 0.05). Before
treatment, there was no significant difference between the
observation and
control groups in the concentrations of
VEGF and
MMP-2 (P > 0.05).
After treatment, the concentrations in the two groups were significantly lower than those before
treatment (P < 0.05), and the concentrations in the
observation group were significantly lower than those in the
control group (P < 0.05). There was no significant difference in the 3-year OS between the
observation and
control groups (P > 0.05). Conclusions Nimotuzumab combined with
cisplatin could improve the conditions of
patients with
nasopharyngeal carcinoma.
After treatment, the expression of
VEGF and
MMP-2 decreased significantly. We speculated that it improves the
survival rate of
patients by reducing the expression of
VEGF and
MMP-2 (AU)