Retinoblastoma (RB) is a common
cancer in
infants and
children. It is a curable
disease; however, a
delayed diagnosis or
treatment makes the
treatment difficult. Genetic
mutations have a central
role in the pathogenesis of RB.
Genetic materials such as RNAs (
coding and non-
coding RNAs) are also involved in the progression of the
tumor.
Circular RNA (
circRNA) is the most recently identified
RNA and is involved in regulating
gene expression mainly through
microRNA sponges. The dysregulation of
circRNAs has been observed in several
diseases and
tumors. Also, various studies have shown that
circRNAs expression is changed in RB
tissues. Due to their
role in the pathogenesis of the
disease,
circRNAs might be helpful as a diagnostic or prognostic
biomarker in
patients with RB. In addition,
circRNAs could be a suitable
therapeutic target to treat RB in a targeted
therapy approach (AU)