Primary melanoma of the oral cavity: A multi-institutional retrospective analysis in Brazil / Melanoma primario de la cavidad bucal: Un análisis retrospectivo multiinstitucional en Brasil
Rodrigues, Bruno Teixeira Gonçalves; Cunha, John Lennon Silva; Albuquerque, Danielle Mendes da Silva; Chagas, Wagner Pinto das; Freire, Nathália de Almeida; Agostini, Michelle; Canedo, Nathalie Henriques Silva; Albuquerque Júnior, Ricardo Luiz Cavalcanti de; Sousa, Silvia Ferreira de; Abrahão, Aline Corrêa.
Med. oral patol. oral cir. bucal (Internet)
; 26(3): e379-e386, May. 2021. ilus, tab
Artículo
en Inglés
| IBECS (España) | ID: ibc-224563
Background:
Melanoma is an aggressive malignant tumor, rarely observed in the oral cavity. The aim of this studywas to describe the clinicopathologic features of a series of oral melanomas.Material andMethods:
A retrospective descriptive study was performed. A total of 15,482 biopsy records from twooral and maxillofacial pathology services in Brazil were analyzed. All cases of oral melanomas were reviewed,and clinical, demographic, histopathological data, treatment, and follow-up status were collected. In addition, im-munohistochemistry stains (pan-cytokeratin AE1/AE3, vimentin, α-SMA, CD45, S-100 protein, HMB-45, MelanA, and Ki-67) were performedResults:
The series comprised of 5 males (71.4%) and 2 females (28.6%), with a mean age of 58.0 ± 9.2 years (range45-69 years) and a 2.51 male-to-female ratio. The gingiva (n = 3, 42.8%) and hard palate (n = 2, 28.6%) were the mostcommon affected sites, presenting clinically as ulcerated swellings with a brown to black color. Cervical lymph nodemetastasis was detected in three patients during the first examination. Microscopically, 6 cases (85.7%) were mela-notic, and one (14.3%) was amelanotic. Most cases (n = 4, 57.1%) presented a predominance of epithelioid cells. S-100and HMB-45 were positive in all cases (n = 7, 100.0%). In contrast, only 4 cases (57.1%) were positive for Melan-A.The proliferative index with Ki-67 was high, with labeling index ranging from 70.0% to more than 90% of positivecells. Five patients died from complications of the tumors after a mean follow-up period of 7.8 months.Conclusions:
Melanoma is an aggressive malignant tumor that rarely occurs in the oral cavity. It occurs mainly inadult and elderly patients and often is diagnosed in advanced stages. The current findings were similar to previousstudies and reflected the characteristics of the services from where lesions were retrieved.(AU)
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
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