Antioxidant defense of children and adolescents with atopic dermatitis: Association with disease severity
Andrade, Roseani da Silva; Souza, Fabíola Isabel Suano de; Aranda, Carolina Sanchez; Mallozi, Marcia Carvalho; Ferreira, Ariel Cordeiro; Barreto, Talita Lemos Neves; Fonseca, Fernando Luiz Affonso; Sarni, Roseli Oselka Saccardo; Solé, Dirceu.
Allergol. immunopatol
; 52(1): 65-70, 01 jan. 2024. ilus, tab
Artículo
en Inglés
| IBECS (España) | ID: ibc-229176
Background:
Atopic dermatitis (AD) is a relapsing, chronic cutaneous inflammatory disease with onset, in general, in early childhood. Chronic skin inflammation is associated with overproduction of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. Oxidative stress, an imbalance between the production of free radicals and antioxidant defense, results in tissue inflammation due to the upregulation of genes that encode inflammatory cytokines. This condition plays an important role in the pathogenesis of AD.Objective:
To compare the antioxidant defense in children and adolescents with AD with that of healthy individuals and to verify the association of antioxidant defense with disease severity and nutritional status.Methods:
Cross-sectional study that evaluated 48 children and adolescents with AD and 25 controls for nutritional assessment (body mass index z score [BMIZ] and height for age z score [HAZ]) and levels of vitamins A, C, E, and D, zinc (Zn), copper (Cu), antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]), high-sensitivity C-reactive protein (CRP) and interleukin 33 (IL-33).Results:
There was no significant difference in the comparison between AD and control groups for serum levels of vitamins (A, D, C, and E), copper, and antioxidant enzymes. Serum zinc levels were higher in the AD group (β = 24.20; 95% CI 13.9534.91; P < 0.001) even after adjusting the BMIZ, HAZ, gender, IL-33, and CRP. Children and adolescents with moderate or severe AD compared to mild AD (SCORAD 36.7±17.4 vs 11.8 ± 3.9; P < 0.001) had lower values of the vitamin E/total lipid ratio (3.68 [0.29;12.63] vs 5.92 [3.27;17.37]; P = 0.013) (AU)
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
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