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Is long-term follow-up solely by imaging tests safe in non-operated pancreatic neuroendocrine tumors?

Polette, Daniela; Busquets, Juli; Secanella Medayo, Lluis; Sorribas Grifell, Maria; Peláez Serra, Núria; Uribe, Catalina; Martinez-Carnicero, Laura; Salord Vila, Silvia; Guerrero, Fernando; Vercher-Conejero, Jose Luis.
Rev. esp. enferm. dig ; 116(4): 209-215, 2024. tab, graf
Artículo en Inglés | IBECS (España) | ID: ibc-232464

Introduction:

the diagnosis of asymptomatic sporadic nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) has increased significantly due to the widespread use of high-resolution imaging tests, which is why the most appropriate management at the time of diagnosis is the subject of debate, as is how to follow-up patients.

Aims:

the objective of this study was to analyze the frequency of imaging and endoscopic studies performed during long-term follow-up.

Methods:

a retrospective review was performed of a database collected between January 2008 and December 2020 of patients with an incidental diagnosis of small NF-PNETs; follow-up was closed in March 2023. The imaging tests performed at the time of diagnosis and long-term follow-up were recorded. Growing less than 1 mm per year has not been considered as a worrisome feature. Follow-up was performed through imaging tests, considering endoscopic cytology for lesions with a faster grow rate.

Results:

fifty-eight patients were included; the median age was 69 years. The initial mean size of the lesions studied was 12.79 mm (5-27). Follow-up was carried out only with computed tomography (CT) or magnetic resonance imaging (MRI). The initial size did not influence the behavior of the lesion in a statistically significant manner. Twenty-eight tumors (45 %) increased in size, with a growth equal to or less than 4 mm in 24 cases. The mean follow-up time was 82.41 months (12-164). No patient developed metastasis or died from PNET progression.

Conclusions:

the follow-up of neuroendocrine tumors of small size can be performed safely with only imaging tests. (AU)
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS