Motor speed predicts stability of cognitive deficitsin both schizophrenic and bipolar I patients at oneyearfollow-up
Salazar-Fraile, J; Balanzá-Martínez, V; Selva-Vera, G; Martínez-Aran, A; Sánchez-Moreno, J; Rubio, C; Vieta, E; Gómez-Beneyto, M; Tabarés-Seisdedos, R.
Eur. j. psychiatry
; 23(3): 184-197, jul.-sept. 2009. tab
Artículo
en Inglés
| IBECS (España) | ID: ibc-85521
Background:
We examined whether motor speed assessed by the fingertapping test predicts generalized and specific stable deficits because of a common pathogenicprocess in bipolar and schizophrenic patients.Methods:
One hundred and two patients underwent a battery of neuropsychologicaltests. Patients with a score of less than one standard deviation from their siblings samplein two assessments with an interval of one year were defined as suffering from stabledeficits because of a common pathogenic process. In addition to univariate analyses, factoranalyses, ordinal logistic regression, and multiple linear regressions were used. A generalscore was also calculated.Results:
No differences were found between schizophrenic and bipolar patients in thedeficits of verbal fluency, shift reasoning ability and executive attention. Schizophrenicpatients had greater persistent cognitive deficit because of a common pathogenic factor inthe verbal memory dimension than bipolar patients. Motor speed predicted the specificdeficits of verbal fluency, shift reasoning, executive attention and the general deficit ofboth bipolar I and schizophrenic patients. Bipolar patients suffered a lesser specific deficitin the verbal memory dimension than schizophrenic patients did, this domain not beingpredicted by motor speed. Motor speed predicted the generalized deficit and the specificdimensions in which schizophrenic and bipolar patients showed no differences.Conclusions:
These results suggest the presence of general and specific stable cognitivedeficits because of a common pathogenic factor related to psychomotor slowness. Motorspeed seems to be suitable endophenocognitype for schizophrenia and bipolar disorder (AU)
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ES1.1
Ubicación: BNCS
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