Preemptive analgesic effectiveness of oral ketorolac plus local tramadol afterimpacted mandibular third molar surgery

Isiordia-Espinoza, Mario A; Pozos-Guillén, Amaury J; Martínez-Rider, Ricardo; Herrera-Abarca, Jorge E; Pérez-Urizar, José

Objective:

The aim of this study was to compare preemptive analgesia of oral ketorolac plus submucous localplacebo with oral ketorolac plus submucous local tramadol after impacted mandibular third molar surgery.Study

design:

A double-blind, randomized, placebo-controlled clinical trial was conducted. Patients were randomizedinto two treatment groups (n = 15 per group) group A, oral ketorolac 10 mg, 30 minutes before surgeryplus submucous local placebo (1 mL saline solution); group B, oral ketorolac 10 mg, 30 minutes before surgeryplus submucous local tramadol (50 mg diluted in 1 mL saline solution). We evaluated the intensity of pain, timefor the first analgesic rescue medication, and total analgesic consumption.

Results:

Pain intensity, number of patients requiring analgesic rescue medication, number of patients in each groupnot requiring analgesic rescue medication, and total analgesic consumption showed statistical significance.

Conclusions:

Preemptive use of oral ketorolac plus submucous local tramadol is an alternative treatment for acutepain after surgical removal of an impacted mandibular third molar (AU)

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