Congenital Zika syndrome is associated with maternal protein malnutrition
BARBEITO-ANDRÉS, J. et al. Congenital Zika syndrome is associated with maternal protein malnutrition. Science Advances, v. 6, n. 2, p. 1-12, Jan. 2020. DOI: https://doi.org/10.1126/sciadv.aaw6284. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954064/pdf/aaw6284.pdf.
Artículo
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| IED | ID: ied-4060
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of proteinmalnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to proteinmalnutrition and infected with a Brazilian ZIKVstrain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seqanalysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal proteinmalnutrition increases susceptibility to CZS. / MRC Zika Rapid Response Grant (MC_PC_15102), FAPERJ (E_03/2017E_03/2017), the Brazilian Ministry of Health (DSAST/SVS 25380.001612/2017-70), and the AAPA Professional Development Grant