Erythrocyte alkaline phosphatase in patients with myotonic muscle disorders / Fosfatasa alcalina en eritrocitos de pacientes con enfermedades musculares miotónicas
Goldemberg, Adriana Lía; Madrid, Enrique Alberto; García, Alicia Mabel; Roubicek, Martín; Trucco, Raúl Esteban.
Invest. clín
; 37(4): 247-53, dic. 1996. ilus
Artículo
en Español
| LILACS | ID: lil-199243
The allosteric behavior of the p-nitrophenyl-phosphatase (EC.3.1.3.1) from membrane erythrocytes was investigated in the following mulltisystemic diseases myotonic dystrophy limb-girdle muscular dystrophy, Charcot-Marie-Tooth and juvenile spinal muscular atrophy; in myotonia congenita. which is not a multisystemic disease, and in healthy controls. The Hill coefficient in F-inhibition in controls was different from that in multisystemic diseases patients but not from that in myotonia congenita patients. Changes in the cooperative type kinetics would suggest that the interaction membrane-enzyme in controls and in patients with neuromuscular disorders is only different for multisystemic diseases
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