Prostaglandins (Pgs) have been shown to inhibit the replication of several
DNA and
RNA viruses. Here we
report the effect of
prostaglandin (PgA1) on the multiplication of a positive strand
RNA virus,
Classical Swine Fever Virus (CSFV) in PK15
cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 µg/ml, which was nontoxic to the
cell, PgA1 inhibits
virus production in 99 per cent. In PgA1 treated
cells the size and number of characteristic
Classical Swine Fever focus decreased in amount.