Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis / Anti LKM-1 and cryoglobulinemia in autoimmune and virus C associated chronic hepatitis
Jirón Vargas, María Isabel; Ardiles Sandoval, Adriana; Parra Blanco, María Adriana; Orellana Valencia, Juana.
Rev. méd. Chile
; 128(3): 273-8, mar. 2000. tab
Artículo
en Español
| LILACS | ID: lil-260185
Background:
Anti liver kidney microsome antibodies (LKM-1) have been recently incorporated to the study and classification of chronic autoimmune hepatitis (HC-A1). The presence of anti LKM-1 antibodies and essential cryoglobulinemia is frequent in virus C associated chronic hepatitis (HC-VC).Aim:
To study the frequency of anti LKM-1 antibodies and cryoglobulin levels in patients with HC-AI, HC-VC and cryptogenic cirrhosis. Patients andmethods:
Forty two patients were studied. Nineteen adult women with classic HC-AI with positive antinuclear or anti smooth muscle antibodies. Five patients of less than 20 years old with HC-AI and negative antinuclear and anti smooth muscle antibodies. Ten adult women with cryptogenic cirrhosis, 4 women and 4 men with HC-VC. Serum samples were obtained at 37C. Antinuclear, anti smooth muscle and anti LKM-1 antibodies were measured by indirect immunofluorescence using Hep-2 cells and rat tissue slices as substrates. Cryoglobulins were determined by the traditional method and cryocrit.Results:
All studied patients were anti LKM-1 negative. All had significant circulating cryoglobulin levels.Conclusions:
In this sample of patients with HC-AI or HC-VC, anti LKM-1 antibodies were not detected but all had cryoglobulinemia
Biblioteca responsable:
CL1.1
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