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Production of L-asparaginase by filamentous fungi

Sarquis, Maria Inez de Moura; Oliveira, Edna Maria Morais; Santos, Alberdan Silva; Costa, Gisela Lara da.
Mem. Inst. Oswaldo Cruz ; 99(5): 489-492, Aug. 2004. graf
Artículo en Inglés | LILACS | ID: lil-386679
L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2 percent proline medium. Both fungi presented the lowest level of L-asparaginase production in the presence of glutamine and urea as nitrogen sources. These results suggest that L-asparaginase production by of filamentous fungi is under nitrogen regulation.
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