Biochemical Relapse for Prostate Cancer Following Radical Prostatectomy: Salvage Radiotherapy Without HormonalTherapy
Fêde, Ângelo B S; Jacinto, Alexandre Arthur; Fagundes, Lívia A; Pellizzon, Antonio Cássio Assis; Novaes, Paulo Eduardo Ribeiro dos Santos; Arruda, Gustavo Viani; Castilho, Marcus Simões; Maia, Maria Aparecida Conte; Silva, Maria Letícia Gobo; Fogaroli, Ricardo César; Salvajoli, João Victor.
Appl. cancer res
; 26(1): 34-39, Jan.-Mar. 2006.
Artículo
en Inglés
| LILACS, Inca | ID: lil-442322
Objectives:
This paper aims to study biochemical control, hormonal therapy-free survival, and prognostic factors related tosalvage radiation for prostate cancer patients submitted to radical prostatectomy (RP) without hormonal therapy (HT) before orduring radiation. Materials andMethods:
from August 2002 to July 2004, 39 prostate cancer patients submitted to RPpresented biochemical failure after achieving PSA nadir (<0.2ng/ml). All patients were submitted to three-dimensional conformalexternal beam radiation therapy (3DC-EBRT) and no patients had received HT. Median age was 62 years, median preoperativePSA was 9.4ng/ml, median Gleason Score was 7. We defined PSA rise above 0.2 as biochemical failure after surgery. Median3DC-EBRT dose was 70Gy, and biochemical failure after EBRT was defined as three consecutive rises in PSA or a single risesufficient to trigger HT.Results:
Biochemical non-evidence of disease (BNED) in 3 years was 72%. PSA doubling time (PSADT)lower than 4 months (p=0.04), and delay to salvage EBRT (p=0.05) were associated to worse chance of successful salvagetherapy. Late morbidity was acceptable.Conclusion:
Expressive PSA control (72% BNED / 3years) could be achieved withsalvage radiotherapy in well-selected patients. The importance of PSADT was confirmed, and radiotherapy should be started asearly as possible. Follow-up is somewhat short, but it is possible to conclude that it is possible to achieve a long interval freefrom hormonal therapy with low rate of toxicity, avoiding or at least delaying morbidity related to hormonal treatment.radiotherapy
Biblioteca responsable:
BR30.1
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