Hepatotoxicity is the alteration of liver structure and function induced by either drugs or other substances. The importance of its proper diagnosisrests on its potential severity. It is the most frequent reason by which the pharmaceutical industry withdraws its products. Tuberculosis is a pandemicinfection affecting a large proportion of the world population. Together with HIV infection it is becoming ever more frequent in Colombia. Tuberculosisposes a special challenge because itstreatment requires the administration, during long periods, of drugs with the potential of inducing liverinjury. In this article some aspects of hepatotoxicity induced by antituberculosis drugs are reviewed, namely epidemiology, risk factors, mechanisms, clinical manifestations, diagnosis, treatment and follow-up.