Introducción: la multifactorialidad del
cancer humano es claramente reconocida. Últimamente se viene asociando
virus de la
familia del
papiloma virus humano (HPV) como condicionante de
carcinoma epidermoide de
esofago . Caso clínico describimos el primer caso a nivel de
Latinoamérica de un
cáncer de esófago con presencia de
papilomavirus humano 16 en un trasplantado renal. La
paciente de 59 años de edad fue sometida a un
trasplante renal once años antes por un
síndrome nefrótico de
causa no determinada. Recibía
inmunosupresores basados en
ciclosporina ,
prednisona y micofenolato de manera initerrumpida. Tres meses antes del
diagnóstico la
paciente empieza a presentar de manera progresiva
disfagia a sólidos asociada a
baja ponderal . El estudio endoscópico alto demostró la presencia de una
lesión proliferativa ulcerada en tercio medio de
esófago . La
biopsia esofágica demostró un
carcinoma epidermoide . El estudio por
PCR para papilomavirus humano subtipo 16 en el tejido tumoral mostró positividad.
Introduction: Being multifactorial is a clearly recognized feature of
cancer in
humans . Recently, some members of the
human papillomavirus family have been associated as conditioning factors for the development of epidermoid esophageal
carcinoma Clinical case This is the first case described in
Latin America of an
esophageal cancer with the presence of a
human papillomavirus -16 in a
patient undergoing
renal transplantation . This
patient , a 59-year old
woman , had a renal
transplant eleven years ago because of a nephritic
syndrome with an unknown cause. She received
immunosuppression using
cyclosporine ,
prednisone and mycophenolate, never interrupting
therapy . Three months before
diagnosis , the
patient presented with
dysphagia to solid
foods , associated to
weight loss . An upper
gastrointestinal endoscopy showed the presence of a proliferative ulcerated lesion in the middle third of the
esophagus . A
biopsy of this lesion showed an
epidermoid carcinoma . A
PCR study looking for
human papillomavirus -16 performed in
tumor tissue was reported as positive.