Adverse drug reactions are common conditions in clinical practice. The majority of these reactions occurs through non-immunologic mechanisms and there are no available validated diagnostic methods for all the situations. Diagnosis is specially difficult in patientswho are using many medications. In Part II of DrugsHypersensitivity authors analyse reactions to specifics drugs groups, as analgesics and NSAID, antibiotics, anticonvulsivants, local anesthetics, latex on surgical environment, neuromuscular relaxants, radiologic contrasts, and the special condition of patients with multiple drugs sensitivities. The knowledge of charatcteristics of the reactions and more appropriate management determine success in diagnosis and patient's guidance.