Polymorphism of the estrogen receptor β gene is related to infertility and infertility-associated endometriosis / O polimorfismo do gene do receptor β de estrógeno está relacionado com infertilidade e endometriose associada à infertilidade
Zulli, Karina; Bianco, Bianca; Mafra, Fernanda Abani; Teles, Juliana Souto; Christofolini, Denise Maria; Barbosa, Caio Parente.
Arq. bras. endocrinol. metab
; 54(6): 567-571, ago. 2010. tab
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en Inglés
| LILACS | ID: lil-557854
OBJECTIVE:
To determine the frequency of the estrogen receptor b gene (ERβ) +1730 G/A polymorphism in infertile women with and without endometriosis and controls. SUBJECTS ANDMETHODS:
Case-control study that included 136 women with endometriosis, 69 women without endometriosis and 209 fertile women as controls. The ERβ gene + 1730 G/A polymorphism was identified by RFLP-PCR (Restriction Fragment Length Polymorphism - Polymerase Chain Reaction).RESULTS:
Genotypes GG, GA and AA of the ERβ gene presented frequencies of 60.3 percent, 38.2 percent and 1.5 percent, respectively, in the women with endometriosis (p < 0.0022). Of the infertile women without endometriosis, 63.8 percent presented the normal homozygous genotype GG, 30.4 percent the GA heterozygous genotype, and 5.8 percent the homozygous mutated genotype AA (p < 0.0275). In the control group, 77.5 percent presented the normal homozygous genotype GG, 21.1 percent the heterozygous genotype GA, and 1.4 percent the homozygous mutated genotype AA.CONCLUSION:
The data suggest that the estrogen receptor β gene (ERβ) +1730 G/A polymorphism can be associated with risk of infertility and endometriosis-associated infertility.
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BR1.1
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