Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre / Biomarcadores tradicionias em narcolepsia: experiência de um centro de sono brasileiro
Coelho, Fernando Morgadinho Santos; Pradella-Hallinan, Márcia; Pedrazzoli, Mario; Soares, Carlos Augusto Senne; Fernandes, Gustavo Bruniera Peres; Gonçalves, André Leite; Tufik, Sergio; Bittencourt, Lia Rita Azeredo.
Arq. neuropsiquiatr
; 68(5): 712-715, Oct. 2010. tab
Artículo
en Inglés
| LILACS | ID: lil-562795
This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at São Paulo, Brazil.
METHOD:
28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1*0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level Normal (N) - Hypocretin-1 higher than 110pg/ml and Lower (L) Hypocretin-1 lower than 110 pg/ml.RESULTS:
Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p=0.0002).DISCUSSION:
This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1*0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1*0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy.
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