Púrpura trombocitopénico inmune asociado a infección por virus hepatitis C en paciente hemofílico: Caso clínico / Immune thrombocytopenic purpura associated to hepatitis C virus infection: Report of one case
Pilleux C, Lilian; Martínez G, Alejandra; Donoso S, Mario; Carrasco L, Cristian.
Rev. méd. Chile
; 138(9): 1140-1143, sept. 2010. ilus
Artículo
en Español
| LILACS | ID: lil-572021
Hepatitis C Virus (HCV) is a cause of secondary chronic immune thrombocytopenic purpura (ITP). We report a 43 year old man with mild Hemophilia A, who received blood transfusions during childhood, that consulted for epistaxis and ecchymoses. The laboratory showed a platelet count of 23.000/mm³, positive HCV serology and elevated transaminases. Steroids administered in pulses followed by oral doses resulted in a partial response requiring a second pulse and association of azathioprine. A steroidal diabetes appeared. Given his refractoriness, splenectomy and liver biopsy were performed. He continued on azathioprine maintaining a platelet count near 50.000/mm³ but continued with bleeding episodes. Liver biopsy showed a chronic active hepatitis.
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