Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits / Atividade antileishmania do 3,4,5-trimetoxi-dihidrocinâmico purificado das frutas de Piper tuberculatum Jacq., Piperaceae, amazônica
Ferreira, Maria Goretty P. R; Kayano, Anderson M; Silva-Jardim, Izaltina; Silva, Tatiany O. da; Zuliani, Juliana P; Facundo, Valdir A; Calderon, Leonardo de A; Almeida-e-Silva, Alexandre de; Ciancaglini, Pietro; Stábeli, Rodrigo G.
Rev. bras. farmacogn
; 20(6): 1003-1006, dez. 2010. graf, tab
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| LILACS | ID: lil-572625
Leishmanicidal activity of the 3-(3,4,5-trimethoxyphenyl) propanoic acid (TMPP) isolated from EtOH extracts of the Amazonian Piper turbeculatum Jacq. fruits was evaluated in vitro using Leishmania amazonensis promastigotes. The TMPP was assayed at concentrations of 1600 to 6.25 µg/mL for 24, 48, 72 and 96 h. Promastigotes viability was analyzed and the IC50 of TMPP was 145 µg/mL.
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