Análise da ação da Himatanthus drasticus na progressão do câncer de pulmão induzido por uretana em camundongos / Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice
França, Wendy Caroline de Souza Costa; Souza, Ana Cláudia Rodrigues Lopes Amaral de; Cordeiro, José Antônio; Cury, Patricia Maluf.
Einstein (Säo Paulo)
; 9(3)july-sept. 2011. tab
Artículo
en Inglés, Portugués
| LILACS | ID: lil-604959
Objective:
To evaluate the effect of janaguba in inhibiting the development of lung cancer in an experimental urethane-induced model.Methods:
a total of 3 mg/kg urethane was injected in 51 Balb-C mice aged 7-13 weeks of life. Janaguba was administered orally daily in two doses 0.04 mL (Group 2, G2) and 0.06 mL (Group 3, G3), for 20 weeks. After this period, the mice were sacrificed and the number of lesions counted.Results:
The mean weight of Group 2 was lower than that of Group 3, and that of Group 1 (Control, G1) (G1 = 35.533 g; G2 = 33.359 g; G3 = 37.125 g). The number of nodules did not differ between groups (mean G1 = G2 = G3 = 1; p = 0.88).Conclusion:
Janaguba had an effect on the growth of mice, but had no influence on the progression of lung cancer in this model.
Biblioteca responsable:
BR500.1
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