Reversible
protein phosphorylation by
protein kinases and
phosphatases is a common event in various cellular processes. The eukaryotic
protein kinase superfamily, which is one of the largest superfamilies of eukaryotic
proteins,
plays several
roles in
cell signaling and
diseases. We identified 482 eukaryotic
protein kinases and 39 atypical
protein kinases in the bovine
genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative
protein kinases, each orthologous to a
human kinase. Whereas orthologous
kinase pairs are, on an average, 90.6 percent identical, orthologous
kinase catalytic domain pairs are, on an average, 95.9 percent identical at the
amino acid level. This
bioinformatic study of bovine
protein kinases provides a suitable framework for further characterization of their functional and structural properties.