OBJECTIVE:
Fetuin-A is a
protein secreted from the
liver that inhibits arterial calcification deposition and can contribute to
insulin resistance.
Hyperthyroidism is also associated with
insulin resistance. It is not known whether
hyperthyroidism has an effect on
fetuin-A levels.
METHODS:
We measured
fetuin-A levels and
homeostasis model of assessment-
insulin resistance before
hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42
patients diagnosed with
hyperthyroidism were enrolled in this study.
Fetuin-A,
insulin, high-
sensitivity C-reactive protein,
fasting blood glucose, free T3 (fT3), free T4 (fT4), and
thyrotropin were measured before and after euthyroidism was established.
RESULTS:
Basal
fasting blood glucose, high-
sensitivity C-reactive protein,
insulin,
c-peptide,
homeostasis model of assessment-
insulin resistance, fT3, fT4 and
fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal
fasting blood glucose (r0.407, p0.008), high-
sensitivity C-reactive protein (r0.523, p<0.0001),
insulin (r0.479, p0.001),
homeostasis model of assessment-
insulin resistance (r0.541, p<0.0001), fT3 (r0.492, p0.001) and fT4 (r0.473, p0.002) were positively correlated with basal
fetuin-A levels. Basal
thyrotropin levels were significantly negatively correlated (r-0.553, p<0.0001) with basal
fetuin-A levels.
CONCLUSION:
Our findings suggest that
hyperthyroidism influences
fetuin-A levels.