Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
Schalcher, Taysa Ribeiro; Vieira, Jose Luiz Fernandes; Salgado, Claudio Guedes; Borges, Rosivaldo dos Santos; Monteiro, Marta Chagas.
Rev. Soc. Bras. Med. Trop
; 46(5): 645-649, Sept-Oct/2013. tab, graf
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| LILACS | ID: lil-691420
Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients. .
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