Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study
Ortiz, Bruno Bertolucci; Araujo Filho, Gerardo Maria de; Araripe Neto, Ary Gadelha de Alencar; Medeiros, Daiane; Bressan, Rodrigo Affonseca.
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 35(4): 432-434, Oct-Dec. 2013. tab
Artículo
en Inglés
| LILACS | ID: lil-697323
Objective:
To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment.Method:
Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria.Results:
Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale (GAF) (p < 0.001). Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine.Conclusion:
Patients with the disorganized subtype of schizophrenia should benefit from clozapine as a second-line agent. .
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BR1.1
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