The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis
Aziret, Mehmet; Irkorucu, Oktay; Reyhan, Enver; Erdem, Hasan; Das, Koray; Ozkara, Selvinaz; Surmelioglu, Ali; Sozen, Selim; Bali, Ilhan; Cetinkunar, Sulleyman; Deger, Kamuran Cumhur.
Clinics
; 69(11): 763-769, 11/2014. tab, graf
Artículo
en Inglés
| LILACS | ID: lil-731108
OBJECTIVES:
Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic colitis.METHODS:
Forty female Wistar albino rats weighing 250-300 g were randomized into five experimental groups (each with n = 8) as follows1) a sham group subjected to a sham surgical procedure and administered only tap water; 2) a control group subjected to a standardized surgical procedure to induce ischemic colitis and administered only tap water; 3) and 4) treatment groups subjected to surgical induction of ischemic colitis followed by the postoperative administration of 5 mg/kg or 10 mg/kg vardenafil, respectively; and 5) a treatment group subjected to surgical induction of ischemic colitis followed by postoperative administration of pentoxifylline at 50 mg/kg/day per day as a single dose for a 3-day period. All animals were sacrificed at 72 h post-surgery and subjected to relaparotomy. We scored the macroscopically visible damage, measured the ischemic area and scored histopathology to determine the severity of ischemia. Tissue malondialdehyde levels were also quantified.RESULTS:
The mean Gomella ischemic areas were 63.3 mm2 in the control group; 3.4 and 9.6 mm2 in the vardenafil 5 and vardenafil 10 groups, respectively; and 3.4 mm2 in the pentoxifylline group (p = 0.0001). The mean malondialdehyde values were 63.7 nmol/g in the control group; 25.3 and 25.6 nmol/g in the vardenafil 5 and vardenafil 10 groups, respectively; and 22.8 nmol/g in the pentoxifylline group (p = 0.0001).CONCLUSION:
Our findings indicate that vardenafil and pentoxifylline are effective treatment options in an animal model of ischemic colitis. The positive clinical effects produced by these drugs are likely due to their influence on the hemodynamics associated ...Asunto(s)
Animales Femenino Colitis Isquémica/tratamiento farmacológico Imidazoles/administración & dosificación Pentoxifilina/administración & dosificación /administración & dosificación Piperazinas/administración & dosificación Colitis Isquémica/patología Colitis Isquémica/cirugía Colon/patología Colon/cirugía Modelos Animales de Enfermedad Hemodinámica/efectos de los fármacos Malondialdehído/análisis Distribución Aleatoria Ratas Wistar Reproducibilidad de los Resultados Sulfonas/administración & dosificación Factores de Tiempo Resultado del Tratamiento Triazinas/administración & dosificación
Biblioteca responsable:
BR1.1
powered by iAHx-2.18-89
Biblioteca Virtual en Salud