Panniculitis is a group of diseases characterized by the presence of inflammatory infiltration in subcutaneous celltissue or adipose panniculous. We describe a 42 year-old whitefemalepatient with dark skin lesions in arms and feet with painful induration under the skin, lasting about 15 years. By cutaneous biopsydiagnose of vasculitis for hipersensibility was made which was treated with prednisone, azathioprine, danazol and endovenous gammaglobulin with no evidence of recovery. The patient was sent to our institute and a surgical skin and subcutaneous celltissuebiopsy was made resulting in septolobular panniculitis with septal predominance and signs of vasculitis. Considering the histopathological classification used and the clinical findings final diagnosis was mixed idiopathic pannicultis, entity not described before in Cuba...