Prevalencia del síndrome de Down en México utilizando los certificados de nacimiento vivo y de muerte fetal durante el periodo 2008-2011 / Prevalence of Down syndrome using certificates of live births and fetal deaths in México 2008-2011
Se construyó una base de datos con 8,250,375 nacimientos ocurridos durante el periodo 2008-2011. El 99.2% correspondió a nacidos vivos y el 0.8% a defunciones fetales. Se diagnosticaron 3,076 casos con SD.
Conclusiones:
La importancia de este trabajo radica en iniciar una vigilancia epidemiológica del recién nacido con SD a nivel nacional y por entidad federativa, utilizando sistemas de información censales disponibles en el país a partir del 2008. Se observó un aumento en el riesgo de tener un hijo con SD a partir de los 35 años de edad materna, como ha sido reportado en otros estudios.
Background:
Down syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation with the clinical presentation of a series of well-defined characteristics. Advanced maternal age has been associated with DS.
A database of 8,250,375 births during the period 2008-2011 was constructed 99.2% were live births with 0.8% of fetal deaths and 3,076 cases diagnosed with DS.
Conclusions:
The importance of this report is to initiate an epidemiological surveillance of newborn cases of DS nationwide and by state using censusinformation systems available in the country since 2008. An increased risk has been observed for having a child with DS since the mother is ≥ 35 years, as has been reported in other studies.