Estimadores de mezcla amerindia basados en métodos serológicos y moleculares / Amerindian admixture estimation based on serological and molecular methods
Pulgar-Alarcón, Iván; Fuentes-Guajardo, Macarena; Llop, Elena; Rothhammer, Francisco.
Rev. méd. Chile
; 143(4): 439-443, abr. 2015. tab
Artículo
en Español
| LILACS | ID: lil-747549
Background: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects and Methods: Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNP´s). Results: Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIM s were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs. Conclusions: In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.
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