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Left Atrial Function in Patients with Chronic Chagasic Cardiomyopathy / Função Atrial Esquerda em Pacientes com Miocardiopatia Chagásica Crônica

Fragata, Claudia da Silva; Matsumoto, Afonso Y; Ramires, Felix J. A; Fernandes, Fabio; Buck, Paula de Cássia; Salemi, Vera Maria C; Nastari, Luciano; Mady, Charles; Ianni, Barbara Maria.
Arq. bras. cardiol ; 105(1): 28-36, July 2015. tab
Artículo en Inglés | LILACS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: lil-755004
<h2>Background:</h2>

Chagas disease is a cause of dilated cardiomyopathy, and information about left atrial (LA) function in this disease still lacks.

<h2>Objective:</h2>

To assess the different LA functions (reservoir, conduit and pump functions) and their correlation with the echocardiographic parameters of left ventricular (LV) systolic and diastolic functions.

<h2>Methods:</h2>

10 control subjects (CG), and patients with Chagas disease as follows 26 with the indeterminate form (GI); 30 with ECG alterations (GII); and 19 with LV dysfunction (GIII). All patients underwent M-mode and two-dimensional echocardiography, pulsed-wave Doppler and tissue Doppler imaging.

<h2>Results:</h2>

Reservoir function (Total Emptying Fraction TEF) (p <0.0001), lower in GIII as compared to CG (p = 0.003), GI (p <0.001) and GII (p <0.001). Conduit function (Passive Emptying Fraction PEF) (p = 0.004), lower in GIII (GIII and CG, p = 0.06; GI and GII, p = 0.06; and GII and GIII, p = 0.07). Pump function (Active Emptying Fraction AEF) (p = 0.0001), lower in GIII as compared to CG (p = 0.05), GI (p<0.0001) and GII (p = 0.002). There was a negative correlation of E/e’average with the reservoir and pump functions (TEF and AEF), and a positive correlation of e’average with s’ wave (both septal and lateral walls) and the reservoir, conduit and pump LA functions.

<h2>Conclusion:</h2>

An impairment of LA functions in Chagas cardiomyopathy was observed.

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Biblioteca responsable: BR1.1