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Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans

Santos, Louisy Sanches dos; Antunes, Camila Azevedo; Santos, Cintia Silva dos; Pereira, José Augusto Adler; Sabbadini, Priscila Soares; Luna, Maria das Graças de; Azevedo, Vasco; Hirata Júnior, Raphael; Burkovski, Andreas; Asad, Lídia Maria Buarque de Oliveira; Mattos-Guaraldi, Ana Luíza.
Mem. Inst. Oswaldo Cruz ; 110(5): 662-668, Aug. 2015. tab, ilus
Artículo en Inglés | LILACS | ID: lil-755900

Corynebacterium diphtheriae, the aetiologic agent of diphtheria, also represents a global medical challenge because of the existence of invasive strains as causative agents of systemic infections. Although tellurite (TeO32-) is toxic to most microorganisms, TeO32--resistant bacteria, including C. diphtheriae, exist in nature. The presence of TeO32--resistance (TeR) determinants in pathogenic bacteria might provide selective advantages in the natural environment. In the present study, we investigated the role of the putative TeR determinant (CDCE8392_813gene) in the virulence attributes of diphtheria bacilli. The disruption of CDCE8392_0813 gene expression in the LDCIC-L1 mutant increased susceptibility to TeO32- and reactive oxygen species (hydrogen peroxide), but not to other antimicrobial agents. The LDCIC-L1 mutant also showed a decrease in both the lethality of Caenorhabditis elegansand the survival inside of human epithelial cells compared to wild-type strain. Conversely, the haemagglutinating activity and adherence to and formation of biofilms on different abiotic surfaces were not regulated through the CDCE8392_0813 gene. In conclusion, the CDCE8392_813 gene contributes to the TeR and pathogenic potential of C. diphtheriae.

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Asunto(s)

Animales Humanos Proteínas Bacterianas/fisiología Caenorhabditis elegans/fisiología Corynebacterium diphtheriae/patogenicidad Células Epiteliales/microbiología Telurio/farmacología Factores de Virulencia/fisiología Antibacterianos/farmacología Adhesión Bacteriana Caenorhabditis elegans/microbiología Corynebacterium diphtheriae/efectos de los fármacos Pruebas de Sensibilidad Microbiana Virulencia
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