The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid-base balance in a PICU population / Efeito do NaCl a 0,9% e do NaCl a 0,45% sobre o sódio, cloreto e equilíbrio ácido-base em uma população de UTIP
Almeida, Helena Isabel; Mascarenhas, Maria Inês; Loureiro, Helena Cristina; Abadesso, Clara S.; Nunes, Pedro S.; Moniz, Marta S.; Machado, Maria Céu.
J. pediatr. (Rio J.)
; 91(5): 499-505, Sept.-Oct. 2015. tab, graf
Artículo
en Inglés
| LILACS | ID: lil-766172
ABSTRACT
OBJECTIVES:
To study the effect of two intravenous maintenance fluids on plasma sodium (Na), and acid-base balance in pediatric intensive care patients during the first 24 h of hospitalization.METHODS:
A prospective randomized controlled study was performed, which allocated 233 patients to groups (A) NaCl 0.9% or (B) NaCl 0.45%. Patients were aged 1 day to 18 years, had normal electrolyte concentrations, and suffered an acute insult (medical/surgical). Main outcome measured change in plasma sodium. Parametric tests t-tests, ANOVA, X 2 statistical significance level was set at a = 0.05.RESULTS:
Group A (n = 130) serum Na increased by 2.91 (±3.9) mmol/L at 24 h (p < 0.01); 2% patients had Na higher than 150 mmol/L. Mean urinary Na 106.6 (±56.8) mmol/L. No change in pH at 0 and 24 h. Group B (n = 103) serum Na did not display statistically significant changes. Fifteen percent of the patients had Na < 135 mmol/L at 24 h. The two fluids had different effects on respiratory and post-operative situations.CONCLUSIONS:
The use of saline 0.9% was associated with a lower incidence of electrolyte disturbances.
Biblioteca responsable:
BR1.1
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