Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles / Impacto da derivação gástrica em Y-de-Roux no perfil inflamatório e lipídico
Oliveira, Cleiton da Silva; Beserra, Bruna Teles Soares; Cunha, Raphael Salles Granato; Brito, Ana Gabriela Estevam; Miranda, Rafaella Cristina Dimbarre de; Zeni, Lúcia Andréia Zanette Ramos; Nunes, Everson Araújo; Trindade, Erasmo Benicio Santos de Moraes.
Rev. Col. Bras. Cir
; 42(5): 305-310, Sept.-Oct. 2015. tab, graf
Artículo
en Portugués
| LILACS | ID: lil-767849
Objective:
To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass.Methods:
We conducted a prospective study, consisting of three moments M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol.Results:
participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050).Conclusion:
Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.
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BR1.1
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