Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa / Estudo experimental sobre os efeitos do subgalato de bismuto no processo inflamatório e de angiogênese em mucosa bucal
Couto, Eduardo Vieira; Ballin, Carlos Roberto; Sampaio, Claudia Paraguaçu Pupo; Maeda, Carlos Augusto Seije; Ballin, Carlos Henrique; Dassi, Camila Soares; Yukari Miura, Lilian.
Braz. j. otorhinolaryngol. (Impr.)
; 82(1): 17-25, Jan.-Feb. 2016. tab, graf
Artículo
en Portugués
| LILACS | ID: lil-775702
ABSTRACT
INTRODUCTION:
Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing.OBJECTIVES:
To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds.METHODS:
This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated.RESULTS:
The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group.CONCLUSION:
Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.
Biblioteca responsable:
BR1.1
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