SARS-CoV-2 Productively Infects Human Gut Enterocytes
Mart M. Lamers; Joep Beumer; Jelte van der Vaart; Kèvin Knoops; Jens Puschhof; Tim I. Breugem; Raimond B.G. Ravelli; J. Paul van Schayck; Anna Z. Mykytyn; Hans Q. Duimel; Elly van Donselaar; Samra Riesebosch; Helma J.H. Kuijpers; Debby Schipper; Willine J. van de Wetering; Miranda de Graaf; Marion Koopmans; Edwin Cuppen; Peter J. Peters; Bart L. Haagmans; Hans Clevers.
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| PREPRINT-BIORXIV | ID: ppbiorxiv-060350
COVID-19, caused by SARS-CoV-2, is an influenza-like disease with a respiratory route of transmission, yet clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2 as demonstrated by confocal- and electron-microscopy. Consequently, significant titers of infectious viral particles were measured. mRNA expression analysis revealed strong induction of a generic viral response program. We conclude that intestinal epithelium supports SARS-CoV-2 replication. One Sentence SummarySARS-CoV-2 infection of enterocytes in human small intestinal organoids
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