Co-infection of influenza A virus enhances SARS-CoV-2 infectivity
Lei Bai; Yongliang Zhao; Jiazhen Dong; Simeng Liang; Ming Guo; Xinjin Liu; Xin Wang; Zhixiang Huang; Xiaoyi Sun; Zhen Zhang; Lianghui Dong; Qianyun Liu; Yucheng Zheng; Danping Niu; Min Xiang; Kun Song; Jiajie Ye; Wenchao Zheng; Zhidong Tang; Mingliang Tang; Yu Zhou; Chao Shen; Ming Dai; Li Zhou; Yu Chen; Huan Yan; Ke Lan; Ke Xu.
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| PREPRINT-BIORXIV | ID: ppbiorxiv-335893
The upcoming flu season in the northern hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental co-infection of IAV with either pseudotyped or SARS-CoV-2 live virus, we found that IAV pre-infection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice co-infected with IAV in vivo. Moreover, such enhancement of SARS-CoV-2 infectivity was not seen with several other viruses probably due to a unique IAV segment as an inducer to elevate ACE2 expression. This study illustrates that IAV has a special nature to aggravate SARS-CoV-2 infection, and prevention of IAV is of great significance during the COVID-19 pandemic.
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