A novel
coronavirus, SARS-CoV-2, was recently identified in
patients with an acute respiratory
syndrome, COVID-19. To compare its
pathogenesis with that of previously emerging
coronaviruses, we inoculated cynomolgus
macaques with
SARS-CoV-2 or
MERS-CoV and compared with historical
SARS-CoV infections. In
SARS-CoV-2-infected
macaques,
virus was excreted from
nose and
throat in absence of clinical signs, and detected in type I and II
pneumocytes in foci of diffuse alveolar damage and mucous glands of the
nasal cavity. In
SARS-CoV-
infection,
lung lesions were typically more severe, while they were milder in
MERS-CoV infection, where
virus was detected mainly in
type II pneumocytes. These data show that
SARS-CoV-2 can cause a COVID-19-like
disease, and suggest that the severity of SARS-CoV-2 infection is intermediate between that of
SARS-CoV and
MERS-CoV. One Sentence SummarySARS-CoV-2
infection in
macaques results in COVID-19-like
disease with prolonged
virus excretion from
nose and
throat in absence of clinical signs.