Sex differences in the decline of neutralizing antibodies to SARS-CoV-2
Ludivine Grzelak; Aurélie Velay; Yoann Madec; Floriane Gallais; Isabelle Staropoli; Catherine Schmidt-Mutter; Marie-Josée Wendling; Nicolas Meyer; Cyril Planchais; David Rey; Hugo Mouquet; Ludovic Glady; Yves Hansmann; Timothée Bruel; Jérôme De Sèze; Arnaud Fontanet; Maria Gonzalez; Olivier Schwartz; Samira Fafi-Kremer.
Preprint
en Inglés
| PREPRINT-MEDRXIV | ID: ppmedrxiv-20230466
The evolution of SARS-CoV-2 humoral response in infected individuals remains poorly characterized. Here, we performed a longitudinal study of sera from 308 RT-qPCR+ individuals with mild disease, collected at two time-points, up to 6 months post-onset of symptoms (POS). We performed two anti-S and one anti-N serology assays and quantified neutralizing antibodies (NAbs). At month 1 (M1), males, individuals > 50 years of age or with a body mass index (BMI) > 25 exhibited higher levels of antibodies. Antibody levels decreased over time. At M3-6, anti-S antibodies persisted in 99% of individuals while anti-N IgG were measurable in only 59% of individuals. The decline in anti-S and NAbs was faster in males than in females, independently of age and BMI. Our results show that some serology tests are less reliable overtime and suggest that the duration of protection after SARS-CoV-2 infection or vaccination will be different in women and men.
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