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Sex-associated differences between body mass index and SARS-CoV-2 antibody titers following the BNT162b2 vaccine among 2,435 healthcare workers in Japan

Shohei Yamamoto; Tetsuya Mizoue; Akihito Tanaka; Yusuke Oshiro; Natsumi Inamura; Maki Konishi; Mitsuru Ozeki; Kengo Miyo; Wataru Sugiura; Haruhito Sugiyama; Norio Ohmagari.
Preprint en Inglés | PREPRINT-MEDRXIV | ID: ppmedrxiv-21262862
Obesity may downregulate vaccine-induced immunogenicity, but the epidemiological evidence for the COVID-19 vaccine is limited, and the sex-associated difference is unknown. It was observed that a higher body mass index was associated with lower titers of spike IgG antibodies against SARS-CoV-2 in men but not in women.