Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of healthcare workers
Wei Wang; Peter Balfe; David W Eyre; Sheila F Lumley; Denise O'Donnell; Fiona Warren; Derrick W Crook; Katie Jeffery; Philippa C Matthews; Elizabeth B Klerman; Jane McKeating.
Preprint
en Inglés
| PREPRINT-MEDRXIV | ID: ppmedrxiv-21265499
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time-of-day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, age, sex, and days post-vaccination on anti-Spike antibody responses in healthcare workers. The magnitude of the anti-Spike antibody response associated with the time-of-day of vaccination, vaccine type, participant age, sex, and days post vaccination. These results may be relevant for optimizing SARS-CoV-2 vaccine efficacy.
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