Vaccine Effectiveness against COVID-19 among Symptomatic Persons Aged >=12 Years with Reported Contact with COVID-19 Cases, February - September 2021
Jessie Chung; Sara Kim; Edward A Belongia; Huong Q McLean; Jennifer P King; Mary Patricia Nowalk; Richard K Zimmerman; Krissy Moehling Geffel; Emily Toth Martin; Arnold Monto; Lois E Lamerato; Manjusha Gaglani; Eric Hoffman; Marcus Volz; Michael L. Jackson; Lisa A Jackson; Manish M Patel; Brendan Flannery.
Preprint
en Inglés
| PREPRINT-MEDRXIV | ID: ppmedrxiv-21267928
Individuals in contact with persons with COVID-19 are at high risk of developing COVID-19, but protection offered by COVID-19 vaccines in the context of known exposure is unknown. Symptomatic outpatients reporting acute onset of COVID-19-like illness and tested for SARS-CoV-2 infection were enrolled. Among 2,229 participants, 283/451 (63%) of those reporting contact and 331/1778 (19%) without known contact tested SARS-CoV-2 positive. Using the test-negative design, adjusted vaccine effectiveness was 71% (95% confidence interval, 49%-83%) among fully vaccinated participants reporting contact versus 80% (95% CI, 72%-86%) among those without. This study supports COVID-19 vaccination and highlights the importance of efforts to increase vaccination coverage.
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