COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE / EFEITO DO ÓLEO DE COCO NAS COMPLICAÇÕES DA DOENÇA HEPÁTICA
Piedade, Giovanna Santos; Klas, Cynthia Fontoura; Rebouças, Rebeca Loureiro; Farias, Gleyce Rodrigues da Costa; Guth, Isabelle; Collaço, Luiz Martins; Marques, Camila Moraes; Kubrusly, Luiz Fernando.
Preprint
en Portugués
| PREPRINT-SCIELO | ID: pps-4142
Background:
Prevention of the progression of cirrhosis with dietary supplementation has been in focus Coconut oil has been suggested.Objective:
To evaluate the effect of coconut oil supplementation in cirrhotic rats.Method:
Forty Wistars were divided control (CO), control + coconut oil (CO + OC), thioacetamide (TAA) and thioacetamide + coconut oil (TAA + OC). TAA was added to water for 13 weeks and coconut oil was administered by gavage. Blood, liver, muscle and nervous tissue samples were obtained for laboratory and histopathological analyses.Results:
AST, ALT, total cholesterol, HDL, LDL, triglycerides were not statistically significant. In histology, even without differences, there was a tendency towards significance regarding the proliferation of bile ducts, fibrotic septa and muscle fiber atrophy between the TAA and TAA + OC groups.Conclusion:
No significant protective effect of coconut oil on liver disease was found.
Biblioteca responsable:
BR1.1
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