PubMed, Ovid SP, Cochrane databases were filtered from years 1980 up to July 2020 for potential papers using relevant MeSH terms and pre-specified inclusion and exclusion criteria independently by two reviewers. Studies that compared pre-emptive analgesicadministration in comparison with placebo for primary tooth extractions in children were evaluated. The outcome sought for were self-reported post-operative pain (patient perceived pain), total number of rescue analgesics consumed in the post-operative follow up period.
Results:
A total of six studies were included for the final evaluation. Most of the studies report lower self-reported post-operative pain scores(n=3), and lower rescue analgesicconsumption(n=3), in pre-emptive group in comparison to placebo.