Acute
fatty liver of
pregnancy is an uncommon, potentially fatal disorder. Between 1998 and 2000, two
patients with acute
fatty liver of
pregnancy presented at the Christian Medical College
Hospital, Vellore. Both
patients were in the thirty-sixth week of
pregnancy.
jaundice and
encephalopathy were the predominant symptoms. Both the
mothers died after they delivered a stillborn
Infant each. The
maternal deaths were due to multiorgan failure and/or
postpartum haemorrhage and
sepsis. The route of delivery was vaginal in both the
patients. Extrahepatic and metabolic
complications in both cases Included
renal failure,
sepsis, hypoglycaemia,
disseminated intravascular coagulation and gastrointestinal
bleeding.
Liver biopsy done in both
patients was consistent with the
diagnosis of acute
fatty liver of
pregnancy. To the best of our
knowledge, this is the first
report from
India on acute
fatty liver of
pregnancy.