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Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.

Mehta, Timir Y; Prajapati, Laxman M; Mittal, Bharti; Joshi, Chaitanya G; Sheth, Jayesh J; Patel, Dinesh B; Dave, Dinkar M; Goyal, Ramesh K.

Indian J Dermatol Venereol Leprol ; 2009 Nov-Dec; 75(6): 579-582

Artículo en Inglés | IMSEAR | ID: sea-140466

Background:

Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.

Aim:

To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.

Methods:

Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.

Results:

Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.

Conclusion:

This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.