Topical
photodynamic therapy (PDT) is an excellent
treatment option for various non-
melanoma skin cancers and precancerous lesions, including
actinic keratosis,
Bowen's disease, and
basal cell carcinoma. The clinical use of PDT includes a broad range of neoplastic, inflammatory, and
infectious skin diseases. There is also anecdotal evidence suggesting the
efficacy of PDT for the
treatment of
keratoacanthomas (KA). We
report a case-series of four
patients with solitary KA confirmed by
histology, treated with topical PDT with methylaminolevulinic
acid (MAL) cream. After three sessions of PDT, the lesions completely disappeared. There was no evidence of
recurrence and excellent cosmetic outcome was achieved after three years of follow-up. Topical
photodynamic therapy with MAL can be a
therapeutic alternative for KA with good clinical and cosmetic outcomes.