Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.
Gadage, Vijaya S; Subramanian, P G; Galani, Komal S; Sehgal, Kunal K; Johari, Sachin P; Ghogale, Vijay S; Badrinath, Y; Ashok, K; Gujral, Sumeet.
Indian J Pathol Microbiol
; 2011 Jul-Sept 54(3): 599-602
Artículo
en Inglés
| IMSEAR | ID: sea-142055
Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.
Texto completo
Documentos relacionados