Your browser doesn't support javascript.
español english

Biblioteca Virtual en Salud

Hipertensión

Home > Búsqueda > ()
Búsqueda Avanzada | Localizar descriptor de asunto
XML
Imprimir Exportar

Formato de exportación:

Exportar

Email
Adicionar mas contactos
| |

The effect of sildenafil on the elasticity of erythrocytes in homozygous sickle cell disease.

Hagley, Abigail C; Younger-coleman, Novie O; Richards, Andrea A; Nwokocha, Chukwuemeka R; Pepple, Dagogo J.
Indian J Med Sci ; 2011 June; 65(6) 243-249
Artículo en Inglés | IMSEAR | ID: sea-145615

Purpose:

One of the features of homozygous sickle cell disease (HbSS) is the impaired elasticity of the erythrocyte membrane that could impede microcirculatory blood flow and cause hypoxia and tissue damage. We investigated the effect of sildenafil, a phosphodiesterase 5 (PDE5) inhibitor that inhibits the breakdown of cyclic guanosine monophosphate (cGMP) resulting in vasodilatation, on the elasticity of HbSS erythrocyte. Materials and

Methods:

Blood samples from ten HbSS patients in steady state was exposed to different doses (5, 10, 20, and 40 μg/mL) of sildenafil and the elasticity of the erythrocytes measured at native hematocrit with the BioProfiler. An equal number of subjects with normal hemoglobin (HbAA) served as the control group.

Results:

There was a marginal increase in elasticity with 5 μg/mL of the drug and this became significant (P < 0.05) with the 10 μg/mL dose. Thereafter, gradual nonsignificant decreases were observed with the 20 and 40 μg/mL doses. A similar trend was observed for the control group. The elasticity values for the HbSS subjects at native hematocrit were significantly (P < 0.05) less when compared with the corresponding concentrations for the HbAA controls. This was reversed at a corrected hematocrit of 45%.

Conclusion:

The result of this study shows that sildenafil caused an initial increase in erythrocyte membrane elasticity in both HbSS and HbAA subjects, and this later decreased with increasing concentration of the drug possibly due to the dual effect of cyclic adenosine monophosphate (cAMP).

Asunto(s)

Adulto Anemia de Células Falciformes/epidemiología Anemia de Células Falciformes/tratamiento farmacológico AMP Cíclico/fisiología GMP Cíclico/fisiología Deformación Eritrocítica/efectos de los fármacos Homocigoto Humanos Piperazinas/uso terapéutico Purinas/uso terapéutico Sulfonas/uso terapéutico Indias Occidentales/epidemiología Adulto Joven
powered by iAHx-2.18-89 Biblioteca Virtual en Salud
pagina inicial | acerca del Portal